Preface: STAT signaling

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

STAT signaling in inflammation

Since their discovery, STAT proteins have been intimately tied to controlling the development of hematopoietic cells that regulate inflammation, and mediating the responses of target cells to inflammatory cytokines. Although our understanding of STAT protein-dependent gene expression during inflammation has grown considerably over the past 15 years, the identification of new cell types that req...

SnapShot: JAK-STAT Signaling

the jak-stat signaling pathway of interferons system: snapshots

interferons (ifns) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. although ifns have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. ifns exert their pleiotropic effects through their multisubunit cell surface recept...

JAK-STAT Signaling: From Interferons

Published, JBC Papers in Press, May 14, DOI 10.1074/jbc.R700016200 Christian Schindler, David E. Levy, and Thomas Decker From the Departments of Microbiology andMedicine, Columbia University, New York, New York 10032, Departments of Pathology and Microbiology, New York University School of Medicine, New York, New York 10016, and Max F. Perutz Laboratories, Department of Microbiology and Immunob...